Form Bio

Founded by Andrew Busey & Ben Lamm in 2022

Design and analyze genetic medicines using AI-driven bioinformatics services

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You can use Form Bio to develop and analyze genetic medicine programs, including AAV gene therapy vectors and CRISPR genome editing. It offers AI-driven vector design screening, batch quality control for contaminants, codon optimization, genome integrity analysis, and population genomics tools. It also supports genome assembly, on-target and off-target editing validation, and manufacturing intelligence. Teams working on drug substance characterization, IND filings, and clinical pipeline development use it to reduce costs and improve yields.

What Form Bio does

Run in silico screening of AAV vector designs to rank candidates by predicted yieldGenerate batch quality control reports showing contaminant levels and genome completenessOptimize codon sequences using an AI model trained on expression and manufacturability dataMap truncation hotspots on a vector map using sequencing dataValidate CRISPR editing efficiency with amplicon or whole-genome sequencing analysisAssemble fragmented DNA reads into complete, annotated genome sequencesAnalyze population-scale genomic data to find trait associations in animalsPrepare regulatory-ready comparability reports for gene therapy drug productsScreens thousands of AAV vector designs in silico before lab testingIdentifies contaminated species and full vs. partial genome distributions in drug batchesMaps truncation hotspots to vector maps to guide design changesAI codon optimization model balances multiple objectives like protein expression and truncation reductionProvides lot-level batch quality control reports for regulatory filingsSupports CRISPR, base editing, and prime editing efficiency analysisEnables population genomics analysis for animal health and breeding programsIntegrates genomic and phenotypic data for disease surveillance and outbreak response